TRIM-NHL proteins in development and disease
نویسندگان
چکیده
منابع مشابه
TRIM-NHL Proteins Take on miRNA Regulation
The TRIM-NHL family of proteins is conserved among metazoans and has been shown to regulate cell proliferation and development. In this issue, Hammell et al. (2009) and Schwamborn et al. (2009) identify two members of this protein family, NHL-2 in worms and TRIM32 in mice, as positive regulators of microRNA function.
متن کاملExploring Potential Germline-Associated Roles of the TRIM-NHL Protein NHL-2 Through RNAi Screening
TRIM-NHL proteins are highly conserved regulators of developmental pathways in vertebrates and invertebrates. The TRIM-NHL family member NHL-2 in Caenorhabditis elegans functions as a miRNA cofactor to regulate developmental timing. Similar regulatory roles have been reported in other model systems, with the mammalian ortholog in mice, TRIM32, contributing to muscle and neuronal cell proliferat...
متن کاملThe TRIM-NHL Protein TRIM32 Activates MicroRNAs and Prevents Self-Renewal in Mouse Neural Progenitors
In the mouse neocortex, neural progenitor cells generate both differentiating neurons and daughter cells that maintain progenitor fate. Here, we show that the TRIM-NHL protein TRIM32 regulates protein degradation and microRNA activity to control the balance between those two daughter cell types. In both horizontally and vertically dividing progenitors, TRIM32 becomes polarized in mitosis and is...
متن کاملThe TRIM-NHL Protein LIN-41 Controls the Onset of Developmental Plasticity in Caenorhabditis elegans
The mechanisms controlling cell fate determination and reprogramming are fundamental for development. A profound reprogramming, allowing the production of pluripotent cells in early embryos, takes place during the oocyte-to-embryo transition. To understand how the oocyte reprogramming potential is controlled, we sought Caenorhabditis elegans mutants in which embryonic transcription is initiated...
متن کاملTRIM-NHL proteins are a family of translational regulators that control cell growth, proliferation and differentiation during development. In Drosophila, loss-of-function of two TRIM-NHL proteins, Brat and Mei- P26, leads to tumorous phenotypes in neural and germline stem cell
TRIM-NHL proteins are a family of translational regulators that control cell growth, proliferation and differentiation during development. In Drosophila, loss-of-function of two TRIM-NHL proteins, Brat and MeiP26, leads to tumorous phenotypes in neural and germline stem cell lineages, respectively. These phenotypes are caused, at least in part, by the expression of dMyc. Here, the authors show ...
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ژورنال
عنوان ژورنال: Seminars in Cell & Developmental Biology
سال: 2015
ISSN: 1084-9521
DOI: 10.1016/j.semcdb.2015.10.017